Not in the middle due to space constraints. If I had a little more space, I would have built it w/ the port centered, but since I could only get ~7.4, I wanted to go w/ a common chamber to allow for better low end. The center port would have forced me to use separate chambers and cut down on the volume each sub 'sees'.
I love the router work there. here's a helpful suggestion. When working with MDF, consider using some solid grained wood as corner bracing. If you cut a square strip of the wood and place it in the corners, it gives you a more secure piece to screw into, as screwing into the edge of MDF almost always causes it to split, unless you take the time to pre-drill and counter-sink every screw, which I also suggest doing anyway.
I used to screw all my boxes together, but I have found that as long as the joints are smooth there is no need. I use 2" 16ga nails and clamps on most boxes now. Save ALOT of time on the build.
I only used screws on this box to pull the bowed bottom panel together (had that sheet of MDF leaned up in the bay for over 2 weeks). I also screwed the 2nd baffle on to allow me to flush trim the port and sub mount holes out right then and there.
As for using screws in MDF, as long as you use 1 5/8th" screws and stay about 4" from any unsecured corner....you stand little chance of splitting the panel. I do clamp before drilling though.
Also, I allow an over night cure time for 95% or my boxes. Other local places clamp/nail them and send them out the door same day even w/ 1000w+ per chamber...I just don't like that. This box is resting in the bay until tomorrow morning, the glue holds the joint, not the nail/screw.
I won't even let a simply sealed 200w 10" box out the door without a minimal of 4hrs to cure.
Edit... I need a new 5/8" round over bit You can see burns on the corners of that brace. Plan to drop the old Skil brand ones and go w/ WhiteSide.