no but if your radio gets left on at all it will kill your battery otherwse not really it's bassiclly the same thing except it will drain your battery.
i have three batteries. But i did have a kill switch for my amps power and my hu's power and it was reversed for some reason, so when my amp was on my hu was off. And the ignition wire on my harness was bad so it wasn't remotely turning my hu or my amp on when i started my car.